REVIEW ON ANOGEISSUS LEIOCARPUS A POTENT AFRICAN TRADITIONAL DRUG. Article (PDF Available) in International Journal of Research in Pharmacy . Common Name: African Birch. Anogeissus leiocarpa. Close-up of the flowers. Photograph by: Marco Schmidt Creative Commons Attribution-Share Alike Abstract Despite the fact that Anogeissus leiocarpus has been in use for many decades in the treatment of many illnesses little is known about its phytochemistry.

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Influence of polyphenols on anogeissus biofilm formation and quorum-sensing. Total polyphenol and total flavonoid were quantified from methanol extract of A. Flavonols and pancreatic cancer risk. Medicinal Plants and Traditional Medicine in Africa.

Anogeissus leiocarpa – Wikipedia

Control of the Anoeissus coli rrnB P1 promoter strength by ppGpp. The results of the liver enzymes and total and direct biluribin were presented in Table 2. Inhibition of pyocyanin production was assessed according to previously described procedures [ 27 ]. The mechanism by which pyocyanin causes cell cycle arrest is related to its redox oxidation—reduction properties, and its ability to reduce molecular oxygen into reactive oxygen species induces low-level, yet persistent, oxidative stress [ 4041 ].

Journal List Medicines Basel v. Determination of serum alkaline phosphatase activity, leiocagpus and direct biluribin were conducted as described by Chawla The flavonoids catechin, isolated from Combretum albiflorum and naringenin have been reported to inhibit QS-regulated virulence factors expression in P. Moreover, the antioxidant polyphenols evidenced are able to reduce the oxidative stress induced by pyocyanin.


Polyphenol content and antioxidant activity of fourteen wild edible fruits from Burkina Faso. By reducing the production of pyocyanin and related oxidative stress within infected tissues in a QS manner, A. Leioocarpus should be noted that steroidal compounds are of importance and interest in pharmacy due to their relationship with such compounds as sex hormones Okwu, Lfiocarpus obtained from the yorubas and south eastern people of Nigeria, indicated that the plant is also used as an antimicrobial agent against bacterial infections Ogunyemi, Anogeidsus activities of extracts from Nigerian chewing sticks.

Pyocyanin was extracted from the supernatant 4 mL with chloroform 2 mL and re-extracted from chloroform with 0. Methanol extract from A. Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa.

The following are available leiocarups at www. Discussion Our in vitro investigations show that methanol extract from A. Some medicinal plants have been reported to present anti-inflammatory activity and wound healing effects without any antibacterial activity [ 2223 ], which suggests a non-antimicrobial modulation of virulence factors. The acute inflammatory response and its regulation.

Production of virulence factors by P.

The founding sponsor had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to aogeissus the results. Antibacterial activity of aqueous extracts of selected chewing sticks.

Violacein content in supernatant was measured by the absorbance at nm. The samples were allowed to clot and centrifuged at rpm for 10 min and serum collected for analysis.


Antibacterial activity of terpenoidal fractions from Anogeissus leiocarpus and Terminalia avicennioides against community acquired infections.

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert’s syndrome. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase ajogeissus rhamnolipid biosynthesis genes. In order to evidence any interference with the expression of quorum sensing QS genes of P. Pyocyanin alters the redox cycle involved in cellular respiration and increases the oxidative stress on host cells [ 1 ].

Polyphenols and flavonoids are also known for their anti-QS potentiality. Anogeissus leiocarpus is a tree of up to 30 m in height, typically m with light green foliage. African Medicinal Plants, Sofowora, A. Optical density reading at nm allows pyocyanin determination.

Anogeissus leiocarpa

Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. In vitro inhibition of mycobacterium smegmatis atcc and a clinical isolate of mycobacterium tuberculosis by some nigerian medicinal plants.

Anogeissus leiocarpus has been shown to be active as antimicrobial agent against gram-positive and gram-negative bacteria such as Leioxarpus aeruginosaStaphylococcus aureus Machido and Ado, ; Taiwo et al.