drug-related adverse reaction leading to caspofungin discontinuation was The printed package leaflet of the medicinal product must state the name and. CANCIDAS® is a sterile, lyophilised product for intravenous infusion that contains a Interpretive standards (or breakpoints) for caspofungin against Candida. CANCIDAS* is a sterile, lyophilized product for intravenous (IV) infusion that CANCIDAS is the first of a new class of antifungal drugs (glucan synthesis.

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Cancidas (caspofungin acetate) dose, indications, adverse effects, interactions from

Patients who remain persistently neutropenic may warrant a longer course of therapy pending resolution of the neutropenia. Patients with hepatic disease, or those with cholestasis, hepatitis or jaundice may require a dose adjustment of caspofungin.

For the treatment of Aspergillus osteomyelitis or infectious arthritis in patients who are refractory to or intolerant of other antifungal therapies. Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment.

Visually inspect prepared infusions for particulate matter and discoloration prior to administration. Increased dosage of tacrolimus may be required.

Monitor patients who develop abnormal liver enzyme concentrations; a risk versus benefit decision for therapy continuation is recommended. If this occurs, discontinue Caspofungin and administer appropriate iinsert.

Plasma concentrations of caspofungin decline in a polyphasic manner following single 1-hour intravenous IV infusions.

For the treatment of respiratory infections i. Caspofungin has not been studied for safety and efficacy in infants less than 3 months of age, including neonates. Caspofungin is contraindicated in patients with known hypersensitivity to any component of this product. In murine models, caspofungin has been shown to have less activity against histoplasmosis than amphotericin B. Infants 3 months and older, Children, and Adolescents. Infants 3 months and older, Children, Adolescents.


Hydrolysis results in two tyrosine amino acid by-products that are rapidly cleared by the kidneys. Five of the jnsert cases and one case of elevated bilirubin were considered possibly related to concomitant therapy; no clinical evidence of nisert or serious hepatic events occurred. Duration of therapy is dependent on clinical response.

Clinical practice guidelines suggest caspofungin as an alternative to posaconazole for aspergillosis prophylaxis in high-risk patients i. There is little excretion or biotransformation during the first 30 hours packwge. Clinical practice guidelines suggest caspofungin as salvage therapy. For the treatment of intraabdominal aspergillosis packagd patients who are refractory to or intolerant of other antifungal therapies.

Moderate Use dichlorphenamide and caspofungin together canicdas caution. After surgical replacement of an infected valve, consider lifelong antifungal therapy.

Standardized susceptibility testing using microbroth dilution methods read at 24 hours are available for Candida sp. Although an increase in efficacy with 70 mg daily has not been demonstrated, limited safety data suggest that an increase in dose to 70 mg daily is well tolerated.

IV echinocandin antifungal Used for aspergillosis, candidemia, esophageal candidiasis, and empiric treatment in febrile neutropenia Fever and infusion-related reactions common. Empirical therapy should be continued until neutropenia resolution. For the treatment of intraabdominal infections i. Esophageal Candidiasis The dose should be 50 mg daily. The mechanism of this interaction has not been cancids but has been reported with tacrolimus; monitor sirolimus blood concentrations and adjust sirolimus dosage as required.


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Dilution Add appropriate dose to mL of 0. The manufacturer recommends against the concomitant use of caspofungin with cyclosporine unless the potential benefit outweighs the risk. The Important Safety Information does not include all the information needed to use Caspofungin Acetate for Injection safely and effectively.

Major If rifampin and caspofungin are administered together in adult patients, the manufacturer recommends increasing the dose of caspofungin to 70 mg daily. Do not mix or co-infuse caspofungin with other medications or infuse with dextrose-containing solutions.

Metabolism occurs by hydrolysis and N-acetylation. Duration of treatment is based on clinical response. Caspofungin is fungicidal against Candida sp. Fresenius Kabi is a global health care company that specializes in medicines and technologies for infusion, transfusion and clinical nutrition.

Empirical therapy should be continued until resolution of neutropenia. Ophthalmological examination is recommended for all patients. Very limited inserr are available. By continuing to browse the website, you consent to our use of cookies.